Just as a relevant point of reference. My wife an I total out at about 350 lbs on our tandem plus another 25 additional pounds of tandem weight versus a single. We run 28c GP 4 Seasons (Conti) at 110 psi rear/105 psi front. I expect we get about 1500 miles out of the rear tire. A single ride weighing that much might want to run higher pressure in the rear since I think proportionately more weight will be on the rear tire. Our wheels are 40h and we've not broken a single spoke in 9000 miles although a large single rider would probably put more stress on the rear wheel.