My Safari and Pt Reyes both have 26x2" tires. I had a 29er Crosstrail with 2" tires. Noticeably more effort needed to spin up the bigger hoops/tires in city traffic. Was fun for bombing around the rough roads,but in the end I decided if I wanted to run fat tires I'd stick with 26".
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C'dale BBU('05 and '09)/Super Six/Hooligan8and 3,Kona Dew Deluxe,Novara Buzz/Safari,Surly Big Dummy,Marin Pt Reyes,Giant Defy 1,Schwinn DBX SuperSport,Dahon Speed Pro TT,Brompton S6L/S2E-X