Fortunately, my derriere is, thus far, reasonably tolerant of my saddles, one cut-out, one solid. It does, however, have a preference for bike shorts.
A couple of years ago, I bought a pair of expensive shorts. The quality of these shorts is outstanding. They have not not worn out with a lot of use. At distances in excess of 45 miles, however, these shorts cause some pain. I have a couple of pairs of cheaper shorts with a less-structured chamois, and these shorts will carry me for 100 miles with no problems.
I've had a couple of saddles that did not work for me, but the construction of the chamois in the shorts is important at least for me.