Forgetting all the *little* details of clothing, calories burned versus consumed, my big issue would be the road conditions would mostly suck.

Yes they plow, sometimes they plow the shoulders. A lot of times, especially west of Minnesota, it's windy, thus a lot of blowing snow. That in turn makes visibility sketchy and the concern would be cars and trucks not seeing you. As well, if the shoulders are marginal, you end up in the traffic lane and with mediocre visibility, you increase the likelihood of getting hit.

Then you end up stopping a lot while awaiting better riding conditions and you are stuck for a few days in towns with maybe one very mediocre restaurant and a motel with no internet and 3 TV channels.

Nope. Not for me.