If you head toward Saranac Lake, you then have 2 options
1) head from there toward Platsburgh and Port Kent, which I've been on many times and is not the most sceanic route
2) from Saranac head toward Lake Placid, then head to Keene, Keenc Valley, Moriah, and then take either the Champlain Bridge or head for the ferry to Charlotte, Vt.
i'd take option 2, much more sceanic in Keene Valley and the ride from Charlotte to Burlington is nice along Lake Champlain.
I'd also check out lakechamplainbikeways.org for routes around the lake