W.r.t. statins, I think I'll wait another 10-15 years for the Institute of Medicine's forthcoming recommendation to discontinue statins for all patients unless there's a specific reason for the prescription.
Slightly more seriously, statins do appear to reduce the risk of CV disease. They also have the minor side effects of muscle pains and accumulative liver damage. That's why I suspect somebody like IOM will eventually look at the whole situation and decide, as they have for PSA and mammograms, that the population-wide costs of the side effects appear to outweigh the benefits. It'll take 10-15 years to get it out of the hands of the cardiologists.
Even more seriously: I exercise regularly. I watch what I eat, and I'm trying to reduce that to lose weight. I suspect, therefore, I'll be in the "harmed more than benefitted by statin" camp.
(But I'm not THAT kind of doctor!)