Lots of great ideas, everyone.
For those who have offered up possible frame options out there on the market, many thanks! (The bummer of having been out of the bike market for 20yrs is that I just don't know many of the good frames that have come and gone.)
Low standover height, ~26lbs or so, ability for full fenders and racks, preferable suspended front fork (w/ lockout) and seat for medical/comfort reasons, in a quality steel.
Keep the possibilities coming. I'll be thinking about each of them.
Thanks, all.