You can certainly adjust the Lefty to be on the soft side as well as running 45-50psi up front and you wont notice most pavement imperfections and jarring compared to a rigid road bike and tire. You could also change out the stem to help take weight off of your shoulders. I don't have many miles on my slate yet but so far it is supremely smooth and comfortable for me. I imagine that just running a bit lower psi on any road bike will ease the suffering a bit but with the slate, you have the big tire and the shock so it's a win win.
