I've been tubeless on my mtb forever. But I haven't ridden road tubeless. My current commuter has a 45 width tire, but I just picked up a set of the 42 sawtooth tires and was considering going tubeless with them.
My only reservation with going tubeless is that in my experience they don't hold air as well as a tube. On my tubed commuter I can go about 2 weeks before I put more air in. On the tubeless mtb the best setup I've ever done is lucky to make it a week before it's too low to even think about riding.