The axle compresses a few tenth of a mm in a 10mm threaded axle. When I adjust the bearings I put a 7/16" nut on the right lock nut and install the QR as tight as if it were on the bike. I then adjust the bearing using the NDS cone and nut so that there is a slight preload. When the QR is opened there is a slight amount of play.
With the new larger rear axles the adjustment is to have no play.
Wheel Bearing adjustment by Jobst Brandt