Those calorie counters are bullsh-t. In my experience, running is way harder than cycling, except if the cycling is mostly uphill or pushing a huge gear very fast. Cycling is, IMO, more equivalent to fast walking. But in general, my experience is, 45 minutes of running is equivalent to 2 or 3 hours of cycling. On the other hand, cycling is easier on the joints, so I can do it more often.