Look at any of my Ironman models. All use an 8/9/10 wheelset, except for the Not Your Daddy's, which uses an 11-sp wheelset.
So the answer is yes, it works, no re-dish, no cold-set. You will quickly develop the technique to insert that rear wheel. With more gears, be sure to use the axle adjusters, as precision is more important.
Some shifter/RD's will cover the distance of 8/9/10, some won't. Generally I match my R shifter to my RD.