Gastroesophageal reflux disease (GERD) is a chronic, relapsing disease that can progress to major complications. Affected patients have poorer health-related quality of life than the general population. As GERD requires continued therapy to prevent relapse and complications, most patients with erosive esophagitis require long-term acid suppressive treatment.

Proton pump inhibitors are accepted as the most effective initial and maintenance treatment for GERD. Oral pantoprazole is a safe, well tolerated and effective initial and maintenance treatment for patients with nonerosive GERD or erosive esophagitis.

"PPIs were never meant to be taken forever," says Marvin M. Lipman, M.D., Consumer Reports chief medical adviser. "You should periodically consult with your doctor about reducing dosage or switching to a less potent acid blocker in combination with dietary modifications."