I like how a 'running during the offseason' thread morphed into 'how many watts does it take to TT at 30mph' thread. This is a bike racing forum after all.
FWIW I have signed up to run a 4 mile turkey trot with my family and I'm not looking forward to it. I started 'training' for it with a 16 minute jog a couple days ago and by the end every step hurt in my knees and ankles. I'll step it up to a 20 minute jog this weekend and consider myself ready. I consider this to be just a distraction from cycling as my legs get really sore after a run and it really is a trade off for me in that more time running means that much less time cycling or in the weight room. If I kept it up for more than a couple weeks I'd expect the DOMS would drop off and it would probably be good for my health but I'm not willing to make that trade off. Also, I live where I can ride outdoors pretty much year round so running wouldn't help get me outside off of a boring trainer.