JRA naw, but riding fast with smooth rubber, sure
tubular tires are marginally more expensive (but you don't pay for a separate tube, it's built in), wheels are lighter, tires may be lighter, and are typically a nicer cushier ride at same pressure.
Also you can run tubular tires at very high PSI for very smooth roads, or really low PSI for rough roads, without pinch flats or blow off.
With latex sealant you can avoid most flats, or repair without removing tire.
The effeto mariposa two sided tape is much easier and faster than gluing