I am currently 280... My bike frame is a 1986 Centurion Facet Aluminum (modern 105 10 speed)... I have over 4000 miles on the frame and 2400 miles of that are on trainer. I am also riding on 24 spoke rims with 2500 miles on them with no issues, including riding some unpaved roads. Wheels have more to do with type of rim and construction than it does spoke count, anyone that tells you otherwise is misinformed.
Older pic has been upgraded to 105 shifters since