I think the frame will be fine. The gearing you describe sounds too high, if it is 1X with a 46T chainring. I have a 46/30T 2X crank with an 11-36T SRAM cassette on my off-road wheelset, and I frequently need that lowest gear. The advantage of the 2020 Domane is they finally made it capable of taking wider tires, which is a major advantage for riding off-road (and on, in my case).