The Cannondale carbon frame has a rear wheel dish that is not standard, has to do with the rear suspension system. If you desire longevity, maybe don’t go with a frame that uses a proprietary suspension system such as the Specialized or carbon Topstone. Maybe go with something that allows larger tire sizes, 45mm or so and maybe a carbon bar, stem and seatpost to soak up a bit of shock.
Lots of bikes, Giant, Trek, Ibis, Niner, Salsa. Also maybe aim for a bike with GRX, allows greater option on the rear gearing to 46 on the cassette, as well the crank will be 48/31or 46/30 which would be a better choice than a 50/34.