I've never paired either my 25 (RIP, went through the laundry) or 130 with anything other than the radar, but I think you can pair them with speed and cadence sensors, heart monitor, etc. So they might work. The 25 I seem to recall only uses the speed/cadence sensors when you are on a trainer, which is kind of an idiotic limitation.
There is a HUGELY useful resource for this stuff, if you haven't come across it: DC Rainmaker
Here is his review of the Edge 25
also, the
Radar
I think the Edge 25 is at the end of its lifetime. My main complaint is the battery lifetime.