About 40 years ago I had my rear wheel come loose, twice. The hub was a Miche Competition, sort of a copy of a Campy Record. The skewers were also Miche. It was a new wheelset to that bike. I had the wheel slip twice, luckily all it did was turn sideways enough to drag the bike to a stop. Only the right side moved forward, and it never came out of the dropout. What I eventually found was that the hub was spaced a bit on the narrow side, something like 115mm, which likely was contributing in me not clamping the skewer down hard enough. I respaced the hub by adding a few spacers under each lock nut and all was fine after that.
I did eventually replace those skewers but not because they slipped, but because the rear skewer snapped about two years later. I think I bought a pair of Cycle Pro skewers at the lbs back then.