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Old 05-10-21, 01:34 PM
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Bikes: Trek Madone 5.2 Dura Ace, Niner RLT9 aluminum, Santa Cruz 5010 CC

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I have a very similar setup to what you're describing: Ultegra shifters, GRX812 rear derailleur, and an 11-42 cassette (crankset is 1x Easton EC90 with a 40 tooth chainring). Works perfectly!

As has been pointed out, it's really not going to work with a 2x crankset and front derailleur.
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