I've done a fair bit of reading, but am still a relatively novice wheelbuilder, so curious what others will chime in with.
From what I remember, you're not likely to get much difference in terms of "comfort" out of your spoke choice. Cross pattern may make a small difference to lateral stiffness, but any difference in vertical compliance is going to be insignificant compared with the tire and frame effects. I'm about your weight with similar use. My wheelset is Farsports shallow carbon rims, 24 front rear CX-ray laced to DT180s. Only complaint I have is occasional disc brake rub when powering out of corners, but that is hub flex, not lateral wheel flex. The wheels feel plenty stiff (and light!) for tons of climbing and descending miles. Hard to go wrong with CX-ray, IMHO.