Yeah, PA bike route S is really horrible in a lot of places, but especially eastbound after Morgantown. I was dot watching someone I ride with occasionally through there and they kept stopping on that stretch, which stressed me out because it wouldn't surprise me if someone were killed on that stretch. And there is also a really big hill. I'm not familiar with it further west, but I think it's bad there too. PA bike routes are almost all bad for riding.
Sorry for taking the OP's thread so far off topic, but Ragbrai isn't really long distance as defined in this subforum.