Sherman Pass from Republic. IIRC, highest paved road in WA. And I think Loup Loup is harder E-W.
And if you really want to drive, the Rim Road around Crater Lake in OR. Make it more challenging by riding up from Ft. Klamath or Diamond Lake, or even Prospect if you are really sick in the head.
Here is the profile for the Diamond Lake start/finish. When I got done circling the lake I didn't want to go down hill for 12 miles. I just wanted off the bike.