I weigh 290 at 6'1" yes I am hefty. I built my own wheels, Velocity Atlas 36 spoke laced to Shimano hubs. They hold up fine, dont go out of true. For tires i run 32mm Gatorskins. I venture onto some rough gravel also.
Bike choice is a Gunnar Crosshairs. I like steel bikes.
My other bikes are a Surly Karate Monkey and a Specialized Fuse aluminum.