Humans have survived in large part because of genetic changes which allowed them to thrive on a huge range of foods, provided the macronutrient mix was within certain boundaries. Blaming the origin of epidemic obesity and metabolic disease on a relative surfeit of one macronutrient or another is not supported by evidence.
There are competing hypotheses regarding the role of carbs in obesity and metabolic syndrome. The carbohydrate-insulin theorists blame the carbs themselves, but animal data and human inpatient feeding studies tend to support boring old old input-output theory of too many calories regardless of source.
That said, the metabolic response to carbs may vary between healthy humans or animals and the very large human population with manifest or sub-clinical metabolic syndrome and insulin insensitivity. It could be that these people do benefit specifically from carb restriction and there is some evidence to support this.
Last edited by MoAlpha; 10-20-22 at 01:55 PM.