After the initial period--cable stretch and the other things mentioned by the other posters--no, your bike will probably not need any attention within 250 miles, assuming everything is set up right in the first place and in working order. Clean and lube as needed, keep an eye on the chain for wear, and you shouldn't have to worry for months and miles. I deal with adjustments as necessary and get a major overhaul at the start of each season. That's it. Of course, problems can arise, but neither adjustments nor tune ups are matters of routine "every 250 miles."
Last edited by lrzipris; 04-24-06 at 06:14 PM.