I run lower than I used to in the late 80's and 90's. I also run the saddle further forward that I used to. All of these changes were in response to knee pain. Turns ou though that it was because the higher/further back position allowed me a lot of leverage and I tended to grind super high gears at lower cadence. The constant strain is what killed me...not the biomechanics....
I agree a lot with what has been said. Ride what feels right. Be willing to give new positions a try, but in the end ride what feels right. Fitting "sciences" are really just rules of thumb for a reason...someone can always demonstrate the opposite working well for them.
People are People (so why should it be)