I just bought a new Madone 5.2 yesterday. The guys in the shop were making some comments about the original LOOK pedals I had swapped from my old bike. (White with Red release, 18 years old)
I am planning on getting KEO's. I asked about Speedplays, and one common input from several differant shops is that the small contact area starts to hurt on a long ride. They said it feels like a small pressure point drilling in to your foot.
I have always been happy with my LOOK pedals.