Cross-chaining isn't something I normally notice. I shoot for a respiratory target by way of desired cadence. If I'm not breathing hard enough, I shift to a harder-to-pedal gear. On my MTB, since I normally stay on the big ring in front, I'm normally in the middle of the rear cassette. On my road bike, since I have only a single ring in front, I'm also normally in the middle of the rear cassette. Cross chaining - not an issue.
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Nishiki road bike, Raleigh road bike, Electra Cruiser Lux 7d, Electra Townie 3i, Electra Townie 1, Whatever I find today!