I had the same problem with my Mavic OP's on Ultegra hubs (making adjustments myself) and I finally took the rear wheel to a LBS who went through and retentioned the wheel and added blue locktite at the end of the process and I've not had a problems since.
Unless you want to become proficient at building wheels I don't think it is worth your time and going through the learning curve to become good at it. But if it is something you think you will enjoy then I say go for it. I've played around with some of my wheels and I can get them true in the rotational plane but not so sure they are radially true when I am finished.
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Uphill or downhill; headwind or tailwind; Pavement or Dirt ... it's all good.