Just thinking out loud here.
Come up with four catchy names for some new neighborhoods to be laid out in the old urbanist style. Things like Old Town, Brick Town, Settlement Town, River Town, etc.
Pre-plat, pre-zone, pre-approve as much as possible for mixed use in a car free friendly way. We all know what that means. Spread out the retail, put places for business and employment within walking distance of the residential, etc. Aim to create entire liveable, small scale communities.
What you want to keep from happening is selling the big parcels to real estate developers who will create giant single-use, car dependent zones. You don't want a square mile of condos here in one place and another square mile of big box stores there on the other side of town.