I would go with 3 and 5 myself. Never having used SRAM before, I test rode a Rush last year with the SRAM triggers and no problem. In fact, I liked it a bit better. It didn't matter to me though, I jumped back on my bike without missing a beat. Now that I have the newer Shimano stuff that opporates either in all one direction or the dual-digit way, I go all one way (thumb). I'm very thankful for this option though.