Originally Posted by
waterrockets
Don't believe anyone who says a stiffer wheel gives you better power transmission.
I wouldn't go quite that far. I was able to discern a bit of a "watch spring" effect with my Shimano R-540's (only four pulling spokes) after switching back and forth between them and the Cosmos (14 pulling spokes) every other ride for about month.
Comfortwise, you're much better off tweaking your cockpit length, saddle height/angle, bar tape/height, stem length, etc. and finding just the right tire and pressure than trying different wheelsets. The difference in "comfort" and "ride quality" between wheelsets is subtle at best.