How much of a hurry are you in? I came up from south of LA to past SF in three days. I watched a guy make it the 400 miles SF to LA in under 23 hours. We both used Interstate 5. Even where the 101 seems to be freeway grade it may be legal for bikes in spots. Call bike shops and clubs along the 101 and ask them.
www.bikely.com may have several routes for you.