I am not familar with CR 200, but HWY 301 when in the rural sections is 65 MPH with a car width shoulder, except in the small towns (Ocala,Waldo,Starke,Lawtey, etc) heading to Jacksonville. When you get to the town of Baldwin (where HWY 301 and I-10 meet) you could take US 90 into Jacksonville or take the baldwin rail trail for 14.5 miles towards Jacksonville.
Hope this helps some..