Front Wheel?
 

I just bought a new DB mountain bike and I had to take the front wheel off to fit it in my car when I went to put the front wheel back on it is hitting the brakes. It looks like the tire is hitting. I have tried to try putting the wheel on several different ways it still seams to be rubbing. I am new to the bike scene so I do not know a lot about bikes. Any help would be greatly appreciated. Thanks

The first and easiest possibility is that you don't have the axle seated firmly in the dropout on one side of the fork, and therefore the wheel is sitting cockeyed and out of position relative to the brakes. Check that first, but since you say the brakes are hitting the tire, it sounds like you may have knocked the brakes out of whack when you removed/installed the wheel. Good instructions here for linear pull brake adjustment: http://www.parktool.com/repair/readhowto.asp?id=21

First did you release the brake cable fom the lever?
http://www.bikewebsite.com/openbrake.jpg

Very good question. But since the wheel was successfully taken off, I'm thinking the noodle must have been released-

True but I have one bike that has fairly narrow tires in it and I can get the wheel off its tight but I can slide it out but getting it back in with out releasing the cable is impossible.

Thanks for all the help guys I will give it a look when I get home today from work

I agree with well biked. I'm guessing that you flip your bike upside down to replace the wheel. If that's the case, you have encountered a common problem. Try setting your bike on it's own wheels, then release and retighten the quick release. My bet is that'll fix it.