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Glipizide

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Old 08-31-12, 03:19 PM
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mgb
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Glipizide

I've been on glipizide for type 2 diabetes for several years now and thought I understood it. I take it half an hour before eating dinner and I always make sure I eat if I've taken it. No problems.

But I like to ride in the evening, 9 or 10 pm about 2 or 3 hours after I've taken the stuff, and there are some short but very steep (20% grade) hills in the neighborhood that I just cannot ride. I've lost a little weight, still over 270, and gotten a little stronger, but I still blow up half way up the hill.

Well yesterday, as an experiment, I didn't take the glipizide. And I got to the top of one of these hills. Panting and out of breath but still on the bike. So I'm assuming that this stuff severely limits my ability to function in the anaerobic range. Do other people have the same experience with this drug? And if so, how do you get around it?
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Old 08-31-12, 06:03 PM
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Perhaps you're lowering your blood sugar too much? As a Type 1 diabetic, the last thing I'd want to do 2-3 hours before exercising was take a medication that I knew was going to lower my blood sugar...
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Old 08-31-12, 06:44 PM
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Glipizide is an oral rapid- and short-acting anti-diabetic drug from the sulfonylurea class. It is classified as a second generation sulfonylurea, which means that it undergoes enterohepatic circulation. Second-generation sulfonylureas are both more potent and have shorter half-lives than the first-generation sulfonylureas.Mechanism of action is produced by blocking potassium channels in the beta cells of the islets of Langerhans. By partially blocking the potassiumchannels, the cell remains depolarized, increasing the time the cell spends in the calcium release stage of cell, which results in signaling leading to calcium influx. The increase in calcium will initiate more insulin release from each beta cell. Sulfonylureas may also cause the decrease of serum glucagon and potentiate the action of insulin at the extrapancreatic tissues.
Originally available in 1984, it is marketed by Pfizer under the brand name Glucotrol in the USA, where Pfizer sells Glucotrol in doses of 5 and 10 milligrams and Glucotrol XL (an extended release form of glipizide) in doses of 2.5, 5, and 10 milligrams. Other companies also market glipizide, most commonly extended release tablets of 5 and 10 milligrams. Wikipedia: Accurate enough for our purposes here. Reproduced under creative commons from http://en.wikipedia.org/wiki/Glipizide
You're getting greater insulin production when you take it. As your weight comes off, your med dosage will likely have to be adjusted.
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Old 08-31-12, 09:11 PM
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You need to check your sugars pre and post ride your going hypoglycemic. Then adjust time dose ect with MD
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Old 08-31-12, 09:22 PM
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Originally Posted by evand View Post
You need to check your sugars pre and post ride your going hypoglycemic. Then adjust time dose ect with MD
All good advice and information. Thanks, guys. I won't mess around and I definitely need to talk with my doc about this as well as doing some additional testing. But something needs to be done. Change my riding schedule I guess.
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Old 08-31-12, 09:33 PM
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Originally Posted by Tom Stormcrowe View Post
You're getting greater insulin production when you take it. As your weight comes off, your med dosage will likely have to be adjusted.
The first sentence there is the important one. Exercise also tends to lower blood sugar, so combining the meds with exercise may lead to a "double whammy" that's forcing the OP's blood sugar too low, possibly to the point of hypoglycemia.

Probably time for the OP to check-in with the doc who prescribed the medication. It might be necessary to modify the dosage or the timing of the meds when exercise is involved.
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Old 09-01-12, 03:17 PM
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I use insulin, but if my sugars are low, I will notice it on a hill. The effect is enough to be called dramatic.

I'm not sure if that's all that is involved. I'm not familiar with the drug you're taking, but some of the chemical cocktails they call drugs might have a lot of side effects.
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