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A vaccine to the market?

 
Old 10-06-20, 09:19 AM
  #76  
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The best vaccine is injecting a little bleach. Hey. It works for the leader of the free world...
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Old 10-06-20, 10:14 AM
  #77  
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The "Trump has it" thread should without question be unlocked. That front and center story is far from being closed, and of course has implications as large as any other for millions of people, vaccine or not.
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Old 10-06-20, 10:17 AM
  #78  
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Originally Posted by Miles2go View Post
The "Trump has it" thread should without question be unlocked. That front and center story is far from being closed, and of course has implications as large as any other for millions of people, vaccine or not.
The mods want anything political or rather with political tones discussed in P&R.
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Old 10-06-20, 10:25 AM
  #79  
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Originally Posted by noisebeam View Post
The mods want anything political or rather with political tones discussed in P&R.
Then it's where the Coronavirus/COVID-19 forum should be moved or started. How do political and governmental actions not directly tie into the spread and treatment of this pandemic?
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Old 10-06-20, 11:11 AM
  #80  
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This thread is going to be an "interesting look back" item one day down the road...
It started w/ 79pmooney posting up about Novavax on July 07. Take a look at their subsequent stock price history:
7/06/20: 79.44
7/07/20: 104.56
8/10/20: 178.51
9/10/20: 92.86
yesterday: 110.17 ... yes, these are the guys to whom the taxpayers handed 1.6 BILLION DOLLARS. yeah, a billion. one company, here's a billion - no, make it 1.6 - yes, take it.
Hope is not a strategy (actually, she's a superspreader at 1600 PA Ave).
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Old 10-06-20, 01:42 PM
  #81  
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^^^^ sometimes NO HOPE is HOPE
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Old 10-08-20, 09:17 AM
  #82  
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Potential COVID-19 vaccines should NOT be affected by mutations to the coronavirus because different strains respond to treatment in the same way, study claims

https://www.dailymail.co.uk/sciencet...udy-finds.html

https://www.nature.com/articles/s41541-020-00246-8
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Old 10-08-20, 09:59 AM
  #83  
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Originally Posted by blacknbluebikes View Post
This thread is going to be an "interesting look back" item one day down the road...
It started w/ 79pmooney posting up about Novavax on July 07. Take a look at their subsequent stock price history:
7/06/20: 79.44
7/07/20: 104.56
8/10/20: 178.51
9/10/20: 92.86
yesterday: 110.17 ... yes, these are the guys to whom the taxpayers handed 1.6 BILLION DOLLARS. yeah, a billion. one company, here's a billion - no, make it 1.6 - yes, take it.
Hope is not a strategy (actually, she's a superspreader at 1600 PA Ave).

Putting that $1.6B number in perspective ... it is less than 1/10,000th of the US economy ($21.44 trillion dollars).
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Old 10-08-20, 11:30 AM
  #84  
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Originally Posted by Biker395 View Post
Putting that $1.6B number in perspective ... it is less than 1/10,000th of the US economy ($21.44 trillion dollars).
I hear what you're saying ... small relative to... but we're talking govt expenditures, not the whole GDP, nonetheless your point stands. Still a lot of money to hand over to one company, and you have to question the insider stock activity, these guys are taking home a lot of cash, exercising stock options granted at single digit prices. Example: Pres of R&D exercised 25k share options priced at $5.95, then sold almost 45k shares at over $106 market. At least we could say "that's bad optics for a company that has not made a profit in the last ELEVEN years." (SEC Form 4 filings).
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Old 10-08-20, 12:18 PM
  #85  
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Originally Posted by blacknbluebikes View Post
I hear what you're saying ... small relative to... but we're talking govt expenditures, not the whole GDP, nonetheless your point stands. Still a lot of money to hand over to one company, and you have to question the insider stock activity, these guys are taking home a lot of cash, exercising stock options granted at single digit prices. Example: Pres of R&D exercised 25k share options priced at $5.95, then sold almost 45k shares at over $106 market. At least we could say "that's bad optics for a company that has not made a profit in the last ELEVEN years." (SEC Form 4 filings).
Oh, I agree that all that should be closely monitored and anyone engaging in insider trading and the like should be prosecuted. Just making the point that even if it is a gamble on the government's part, it is a small one given what is at stake. This is essentially being managed the same way the military procures weapons with significant development risk (so high, that none of the potential bidders can reasonably risk it). They give competing entities cost-plus contracts to explore it, with the hope that at least one of them will be viable, and once that one is proven, competitively bid out the winning design for further development or production.

Apparently, there are now 7 vaccines with development being paid for by the US?

https://www.usatoday.com/story/news/...es/5575206002/

I have no idea which or any of the vaccines under development will succeed (if any), just as the military doesn't know that any of the cost-plus contracts will pan out to a weapon that will work. That doesn't mean that paying for the development is a bad risk, or that the money was wasted. But if the money is just used to line the pockets of the companies involved ... yea ... jail time is in order.
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Old 10-13-20, 12:15 AM
  #86  
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Johnson & Johnson pauses COVID-19 vaccine study over participant illness

https://nypost.com/2020/10/12/johnso...ipant-illness/
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Old 10-16-20, 12:52 PM
  #87  
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Coronavirus update: Pfizer seeks vaccine authorization in November

https://www.yahoo.com/finance/news/c...135756615.html
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Old 10-16-20, 01:58 PM
  #88  
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Originally Posted by Biker395 View Post
Coronavirus update: Pfizer seeks vaccine authorization in November

https://www.yahoo.com/finance/news/c...135756615.html
If you read the letter from Pfizer chairman Albert Bourla, you will see that the November date is based on the two month safety period after the last dose was given. They actually don't know if they will have efficacy data by then. The vaccine developers are blinded as to the efficacy data and they will only know when the committee of independent scientists advise them.

As Pfizer is blinded to who received the vaccine versus the placebo, a committee of independent scientists will review the complete data and they will inform us if the vaccine is effective or not based on predetermined criteria at key interim analysis points throughout the trial.
So at this point they are guessing that the vaccine will be effective.

Still, positive news, lets keep our fingers crossed.

Pfizer letter
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Old 10-16-20, 02:13 PM
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Thanks for the context.
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Old 10-19-20, 10:02 PM
  #90  
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In China there is a large demand for an unapproved vaccine that is still in trials.
The eastern Chinese city of Yiwu has stopped the sale of a coronavirus vaccine after dozens of people demanded to be inoculated over the weekend, underlining the popularity of the treatment that has not even completed late-stage clinical trials.

Hundreds of people in Yiwu stood in line for a coronavirus vaccine after the government opened up bookings to the general public, the BBC reported on Sunday. The local government had said on Friday it would allow people to be vaccinated on an “emergency use” basis, a day after the neighboring city of Jiaxing announced the same.
The high demand for the vaccine in China highlights the potential shortfall that local governments could face once a treatment is approved. Unlike in the United States — where a growing number of polls have found that many people would not get a coronavirus vaccine in part because they feel the Trump administration is pushing for its approval before fully weighing the safety and efficacy data — many people in China are flocking to get one.

China has indicated it would expand the number of “emergency users” for a vaccination program, saying it plans to target people at higher risk of being exposed to the virus such as travelers and health care workers. Tens of thousands of people have already been vaccinated, including government officials and executives of vaccine companies.
I wonder if a significant portion of the Chinese public are anti-vaxers like in North America? Somehow I doubt it

https://www.nytimes.com/live/2020/10...emand-in-china
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Old 10-19-20, 10:08 PM
  #91  
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I suspect anti-vaxers would be much less vocal about their beliefs in that culture.
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Old 10-19-20, 10:14 PM
  #92  
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Originally Posted by jon c. View Post
I suspect anti-vaxers would be much less vocal about their beliefs in that culture.
Yes. Maybe that is the upside of an authoritarian police state.
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Old 10-20-20, 12:08 PM
  #93  
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Moderna’s COVID-19 vaccine could get emergency approval in December

https://nypost.com/2020/10/20/modern...y-by-december/
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Old 10-21-20, 08:37 AM
  #94  
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Originally Posted by CycleryNorth81 View Post

Moderna’s COVID-19 vaccine could get emergency approval in December

https://nypost.com/2020/10/20/modern...y-by-december/
This is the same situation as Pfizer's vaccine. The timeline is set by the fact that they have to have at least 60 days since the last dose before they can apply for emergency use. They are hoping that will have efficacy data by then. The article says that they need to have 53 symptomatic infections in the placebo arm.

Moderna will analyze how well the vaccine is working when 53 people in its Phase 3 study develop symptomatic cases of COVID-19, the Journal reported. That analysis is expected to take place in November, though the exact timing is tough to predict “because it depends on the cases, the number of people getting sick,” Bancel said.
If it isn't clear cut they will wait until they have 106 cases.
However, it’s possible that the vaccine won’t be deemed effective enough when the initial data is analyzed next month, the paper reported. Moderna would then reportedly conduct a second analysis when 106 people get sick with the coronavirus.
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Old 10-21-20, 09:01 AM
  #95  
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Originally Posted by skookum View Post
This is the same situation as Pfizer's vaccine. The timeline is set by the fact that they have to have at least 60 days since the last dose before they can apply for emergency use. They are hoping that will have efficacy data by then. The article says that they need to have 53 symptomatic infections in the placebo arm.



If it isn't clear cut they will wait until they have 106 cases.
I hope they can work out the logistics (glass vial procurement, distribution) too.
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Old 10-21-20, 09:07 AM
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Healthy volunteers look set to be infected with Covid as part of new U.K. 'challenge trial'

https://news.yahoo.com/healthy-volun...063036273.html
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Old 10-21-20, 01:58 PM
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Giving healthy people an unpredictable virus we've only been studying for 9 months? Ethically dubious at best.
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Old 10-23-20, 02:56 PM
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Distribution obstacles.

US faces major hurdles for COVID-19 vaccine distribution: Vaccine advisory committee

https://finance.yahoo.com/news/us-fa...205158048.html
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Old 10-27-20, 09:45 PM
  #99  
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Dr Fauci warns that early COVID-19 vaccines will only prevent symptoms from arising - not block infection

https://www.dailymail.co.uk/news/art...infection.html
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Old 10-28-20, 11:23 AM
  #100  
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Originally Posted by blacknbluebikes View Post
Giving healthy people an unpredictable virus we've only been studying for 9 months? Ethically dubious at best.

Nobody is being given " an unpredictable virus." Not sure what you mean by this, but no vaccine program involves injecting people with Covid-19. Basically, the vaccines are viruses that produce the CV-19 protein or cause your cells to produce that protein. The theory is that the immune system will develop antibodies that attack that protein. The protein is not the part of the COVID-19 virus that causes the harm. .
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