A nasal spray may block COVID...
11-08-20, 07:00 AM
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genec
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A nasal spray may block COVID...
This just in, and in very very early testing, with ferrets... a nasal spray, that could block COVID infection for 24 hours.
https://bgr.com/2020/11/07/coronavir...popeptide/amp/
https://finance.yahoo.com/amphtml/ne...204611720.html
https://bgr.com/2020/11/07/coronavir...popeptide/amp/
https://finance.yahoo.com/amphtml/ne...204611720.html
Columbia University researchers have developed a nasal spray that has successfully prevented COVID-19 infections in tests with ferrets as well as a 3D model of human lungs.
The lipopeptide (that is, a lipid and peptide combination) prevents the coronavirus from fusing with a target cell’s membrane by blocking a key protein from adopting a necessary shape. It should work immediately and last for at least 24 hours. It’s also affordable, lasts a long time, and doesn’t need refrigeration.
The lipopeptide (that is, a lipid and peptide combination) prevents the coronavirus from fusing with a target cell’s membrane by blocking a key protein from adopting a necessary shape. It should work immediately and last for at least 24 hours. It’s also affordable, lasts a long time, and doesn’t need refrigeration.
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11-08-20, 12:55 PM
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Although better than getting the Corona virus, that doesn't sound too healthy for your lungs, and you can still get the virus by touching your mouth or eyes with your fingers.
I doubt it will actually be that effective in real life, but I'm not a medical researcher.
I doubt it will actually be that effective in real life, but I'm not a medical researcher.
11-08-20, 01:43 PM
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Originally Posted by CargoDane
Although better than getting the Corona virus, that doesn't sound too healthy for your lungs, and you can still get the virus by touching your mouth or eyes with your fingers.
I doubt it will actually be that effective in real life, but I'm not a medical researcher.
I doubt it will actually be that effective in real life, but I'm not a medical researcher.
Also, the spread by touch appears to be quite unusual, it's almost all airborne. And who's to say whether the virus could spread from eye or mouth contact if access to the lungs and nose are both blocked.
The only thing I agree with in your post is that you're not a medical researcher. It sounds promising, I hope it works.
11-08-20, 01:52 PM
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Originally Posted by livedarklions
None of us have any idea how effective it might be in real life, but "doesn't sound too healthy for your lungs" is absurd. They're going to test for safety, but until then your "gut reaction" is absolutely worthless. People inhale all sorts of medications without harmful effects. This may or may not fall into that category.
Also, the spread by touch appears to be quite unusual, it's almost all airborne. And who's to say whether the virus could spread from eye or mouth contact if access to the lungs and nose are both blocked.
The only thing I agree with in your post is that you're not a medical researcher. It sounds promising, I hope it works.
Also, the spread by touch appears to be quite unusual, it's almost all airborne. And who's to say whether the virus could spread from eye or mouth contact if access to the lungs and nose are both blocked.
The only thing I agree with in your post is that you're not a medical researcher. It sounds promising, I hope it works.
Being an asthmatic and a sufferer from MCS due to black mold in a building I once lived in, I know how little it takes to screw up my lungs. And something that prevents things from fusing with the cell membrane doesn't sound like it does something good to your lungs if used every 24 hours.
And, no, I'm not a medical researcher, but neither are you. The only living organism they have tested this on is ferrets. The model of human lungs were obvisouly to see if they could get it into every nook and cranny. The ferrets can't actually tell what is happening, nor do we have long term data - not even on the ferrets.
Even if it works, you only need a "soft entry point" to get the virus, which means that if you touch your mouth or eyes with virus on the fingers, you can still get it. That's why we use hand sanitizer with a large amount of alcohol in it and use soap to wash our hands very thoroughly.
Yes, they will do more testing as they should, but I don't have particularly high hopes that this will be for everyone or even for most.
Last edited by CargoDane; 11-08-20 at 01:59 PM.
11-08-20, 02:25 PM
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Originally Posted by CargoDane
My first reaction is worth at least as much as yours.
Being an asthmatic and a sufferer from MCS due to black mold in a building I once lived in, I know how little it takes to screw up my lungs. And something that prevents things from fusing with the cell membrane doesn't sound like it does something good to your lungs if used every 24 hours.
And, no, I'm not a medical researcher, but neither are you. The only living organism they have tested this on is ferrets. The model of human lungs were obvisouly to see if they could get it into every nook and cranny. The ferrets can't actually tell what is happening, nor do we have long term data - not even on the ferrets.
Even if it works, you only need a "soft entry point" to get the virus, which means that if you touch your mouth or eyes with virus on the fingers, you can still get it. That's why we use hand sanitizer with a large amount of alcohol in it and use soap to wash our hands very thoroughly.
Yes, they will do more testing as they should, but I don't have particularly high hopes that this will be for everyone or even for most.
Being an asthmatic and a sufferer from MCS due to black mold in a building I once lived in, I know how little it takes to screw up my lungs. And something that prevents things from fusing with the cell membrane doesn't sound like it does something good to your lungs if used every 24 hours.
And, no, I'm not a medical researcher, but neither are you. The only living organism they have tested this on is ferrets. The model of human lungs were obvisouly to see if they could get it into every nook and cranny. The ferrets can't actually tell what is happening, nor do we have long term data - not even on the ferrets.
Even if it works, you only need a "soft entry point" to get the virus, which means that if you touch your mouth or eyes with virus on the fingers, you can still get it. That's why we use hand sanitizer with a large amount of alcohol in it and use soap to wash our hands very thoroughly.
Yes, they will do more testing as they should, but I don't have particularly high hopes that this will be for everyone or even for most.
The difference between you and me is that I know that my first reaction is completely meaningless and you seem hell-bent on convincing people (unconvincingly) that your first reaction is worth note.
You might have noted that recommendations for self-protection moved away from near-obsessive hand cleansing and towards mask wearing. That's because all of the relevant evidence suggests that spread by hand is relatively quite rare.
Not sure why your various ailments are supposed to qualify you as some sort of expert, but I'm pretty sure one of them isn't a real thing. I'll leave that to another forum.
11-08-20, 02:39 PM
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Originally Posted by livedarklions
The difference between you and me is that I know that my first reaction is completely meaningless and you seem hell-bent on convincing people (unconvincingly) that your first reaction is worth note.
You might have noted that recommendations for self-protection moved away from near-obsessive hand cleansing and towards mask wearing.
I live in Denmark, perhaps we are better informed here. Mask use is not "instead of washing hands and using sanitizer".
That's because all of the relevant evidence suggests that spread by hand is relatively quite rare.
Not sure why your various ailments are supposed to qualify you as some sort of expert, but I'm pretty sure one of them isn't a real thing. I'll leave that to another forum.
A mask mainly works because it stops spittle, it doesn't actually protect you as you breathe in around it, not through it. It does, however, stop you from touching your mouth and nose.
But, again, your reaction is way over the top and really has no bearing on reality either. Did you know that the WHO now have "shunned" Remdesevir? There were medical researchers (from another big corp) behind that "treatment" too. Just because something is done by researchers doesn't mean their hypothesis will be born out in reality.
Last edited by CargoDane; 11-08-20 at 02:56 PM.
11-08-20, 02:51 PM
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Originally Posted by CargoDane
No I don't. You're completely overreacting.
No it didn't. They complement each other.
I live in Denmark, perhaps we are better informed here. Mask use is not "instead of washing hands and using sanitizer".
Sure
It doesn't qualify my "as an expert". It's just that I know that it takes very little for my lungs to react due to the MCS. Much less than most people.
Masks mainly works because it stops spittle, it doesn't actually protect you as you breathe in around it, not through it. It does, however, stop you from touching your mouth and nose.
But, again, your reaction is way over the top and really has no bearing on reality either. Did you know that the WHO now have "shunned" Remdesevir? There were medical researchers (from another big corp) behind that "treatment" too. Just because something is done by researchers doesn't mean their hypothesis will be born out in reality.
No it didn't. They complement each other.
I live in Denmark, perhaps we are better informed here. Mask use is not "instead of washing hands and using sanitizer".
Sure
It doesn't qualify my "as an expert". It's just that I know that it takes very little for my lungs to react due to the MCS. Much less than most people.
Masks mainly works because it stops spittle, it doesn't actually protect you as you breathe in around it, not through it. It does, however, stop you from touching your mouth and nose.
But, again, your reaction is way over the top and really has no bearing on reality either. Did you know that the WHO now have "shunned" Remdesevir? There were medical researchers (from another big corp) behind that "treatment" too. Just because something is done by researchers doesn't mean their hypothesis will be born out in reality.
You do you. As usual, you're flailing about, and it's not worth my time.
11-08-20, 02:54 PM
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Originally Posted by livedarklions
You do you. As usual, you're flailing about, and it's not worth my time.
11-08-20, 04:42 PM
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I contracted the virus a little over a month ago and am mostly recovered. The incubation period was about 5 days from contact, which developed into a dry cough, then fever and a pneumonia-like cough. Immediate loss of mental clarity and energy.
Treated the cough (lasted two weeks) with guaifenesin, dextro-methorphan, acetaminophen for the fever (lasted two-three nights) doubled up on vitamin C and zinc ever since. Other family members also suffered nausea gastrointestinal distress.
Hopefully there will be effective preventatives which pass muster. I would favor a nasal spray, but my wife would not.
Stay healthy!
Treated the cough (lasted two weeks) with guaifenesin, dextro-methorphan, acetaminophen for the fever (lasted two-three nights) doubled up on vitamin C and zinc ever since. Other family members also suffered nausea gastrointestinal distress.
Hopefully there will be effective preventatives which pass muster. I would favor a nasal spray, but my wife would not.
Stay healthy!
11-08-20, 04:44 PM
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Originally Posted by reconnaissance
I contracted the virus a little over a month ago and am mostly recovered. The incubation period was about 5 days from contact, which developed into a dry cough, then fever and a pneumonia-like cough. Immediate loss of mental clarity and energy.
Treated the cough (lasted two weeks) with guaifenesin, dextro-methorphan, acetaminophen for the fever (lasted two-three nights) doubled up on vitamin C and zinc ever since. Other family members also suffered nausea gastrointestinal distress.
Hopefully there will be effective preventatives which pass muster. I would favor a nasal spray, but my wife would not.
Stay healthy!
Treated the cough (lasted two weeks) with guaifenesin, dextro-methorphan, acetaminophen for the fever (lasted two-three nights) doubled up on vitamin C and zinc ever since. Other family members also suffered nausea gastrointestinal distress.
Hopefully there will be effective preventatives which pass muster. I would favor a nasal spray, but my wife would not.
Stay healthy!
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11-08-20, 04:47 PM
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Originally Posted by reconnaissance
I contracted the virus a little over a month ago and am mostly recovered. The incubation period was about 5 days from contact, which developed into a dry cough, then fever and a pneumonia-like cough. Immediate loss of mental clarity and energy.
Treated the cough (lasted two weeks) with guaifenesin, dextro-methorphan, acetaminophen for the fever (lasted two-three nights) doubled up on vitamin C and zinc ever since. Other family members also suffered nausea gastrointestinal distress.
Hopefully there will be effective preventatives which pass muster. I would favor a nasal spray, but my wife would not.
Stay healthy!
Treated the cough (lasted two weeks) with guaifenesin, dextro-methorphan, acetaminophen for the fever (lasted two-three nights) doubled up on vitamin C and zinc ever since. Other family members also suffered nausea gastrointestinal distress.
Hopefully there will be effective preventatives which pass muster. I would favor a nasal spray, but my wife would not.
Stay healthy!
Glad you and your family are okay.
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11-08-20, 05:13 PM
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As fate would have it, one of my daughters (living on her own) is a nurse. She and two younger siblings (who live with us) were in a car together all day before she had symptoms, and four days later she called us to let us know she was feeling symptomatic, was tested next day and the rest is history. Fortunately, we were able to remain quarantined (for three, almost four weeks) and didn't pass it along to anyone else.
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11-08-20, 05:36 PM
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Originally Posted by reconnaissance
As fate would have it, one of my daughters (living on her own) is a nurse. She and two younger siblings (who live with us) were in a car together all day before she had symptoms, and four days later she called us to let us know she was feeling symptomatic, was tested next day and the rest is history. Fortunately, we were able to remain quarantined (for three, almost four weeks) and didn't pass it along to anyone else.
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11-09-20, 07:48 AM
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Originally Posted by reconnaissance
As fate would have it, one of my daughters (living on her own) is a nurse. She and two younger siblings (who live with us) were in a car together all day before she had symptoms, and four days later she called us to let us know she was feeling symptomatic, was tested next day and the rest is history. Fortunately, we were able to remain quarantined (for three, almost four weeks) and didn't pass it along to anyone else.
Originally Posted by 10 Wheels
Thanks much
I don't live in the area, but I second that gratitude. I'm currently suffering from a lung ailment that's making me feel especially vulnerable to a COVID infection, and am very glad that people such as you and your entire family behave so responsibly.
11-10-20, 11:53 AM
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Interesting concept.
I wonder how this will be marketed.
The ultimate use of the drug will also impact the general safety as well as testing protocols.
Metabolism, Excretion, & Metabolites?
I wonder how this will be marketed.
- Daily dose, and continue with your daily life?
. - Dose for special occasions such as going to a wedding, or going to the dentist.
Metabolism, Excretion, & Metabolites?
11-10-20, 03:04 PM
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Originally Posted by CliffordK
Interesting concept.
I wonder how this will be marketed.The ultimate use of the drug will also impact the general safety as well as testing protocols.
Metabolism, Excretion, & Metabolites?
I wonder how this will be marketed.
- Daily dose, and continue with your daily life?
. - Dose for special occasions such as going to a wedding, or going to the dentist.
Metabolism, Excretion, & Metabolites?
I think this is a back-up strategy in case the vaccines don't actually work. Essentially, this would be like taking a daily vaccine.
