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Donít we already know the answer to this?

Old 09-07-23, 09:14 AM
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Donít we already know the answer to this?

I saw this brief item in the local fish wrap today. Maybe they were hungry for content??? I actually sent a message to the editor asking why itís ďnews.Ē Itís a ďDog Bites ManĒ topic. Yeah, good that itís being studied (again). But donít we already know the results? ó Dan

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Old 09-07-23, 10:20 AM
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If "we" already know the answer, why don't you as a representative of "we" send the answer to Kevin Murach and request that he either return the $2.5 million to the NIH, or send it to "Us"?
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Old 09-07-23, 10:24 AM
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We know quite a few of the answers, but not all the possible answers since the previous answers generated a lot more questions.



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Old 09-07-23, 11:25 AM
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Understanding the mechanism by which exercise protects muscle has potential clinical, scientific, and economic importance. Given NIH funding lines these days, this must have been a pretty damn good proposal.
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Old 09-07-23, 12:02 PM
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MYC protein.
Hope it is plant based.

As an 'aged' and active cyclist + hiker = the results really don't mean much to me. I just have to look at the physical health of people my age, 70+.

Saw a dermatologist on Tuesday for a routine skin cancer check. Never met the female Dr. before the appt. "Nice legs, cyclist?" Guess maybe it was a give-away as I had shaved the legs just before Labor Day. It did make me smile.

edit: On a similar note.
They should also give grants to researchers in Kentucky, Alabama, Mississippi and W. Virginia = the only 4 States with a shorter life expectancy than Arkansas. . These 5 States also have the highest levels of obesity in the Country. Duh.

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Old 09-07-23, 12:16 PM
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I'd give the possible study results a "fascinating" rating. AFAIK, we don't know squat about that particular subject, which seems to me, with no doctorate in the organic chem of humans, very complicated. It's getting hard to read study results anymore with all this examination of subcellular chemistry. We have to rely on interpreters, trying to judge their possible monetary, political and scientific biases. Sure, we know exercise is good for us and especially for us geezers, but more details of the effect should be helpful, even though it might be in the realm of knowing more about the origin of galaxies. "So little time, so much to know!"
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Old 09-07-23, 12:44 PM
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Ask parrots why they live so long. They can talk. LOL
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Old 09-07-23, 12:50 PM
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While we are taught in elementary school that exercise benefits us and we hopefully understand that it will lead to better health in aging, there is still a need for continued research. I'm sure the study is not going to end with a single paragraph that says old people can still exercise.

And there are grant dollars going to things that make less sense spending money on than this.
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Old 09-07-23, 01:06 PM
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A quick search says MYC protein plays a role in the control of cell growth. Pretty sure this project is aimed at laying out some of the critical steps between the mechanical effect of exercise and muscle cell growth or preservation, and to find out how aging affects them. One possible outcome from this type of work could be "exercise in a pill" for, say, people on prolonged bedrest.
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Old 09-07-23, 02:18 PM
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A futurist - exercise in a pill - how wonderfully American.
Let's have a suntan pill too, so we can look outdoorsy year-round. Just not too Orangey.
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Old 09-07-23, 05:49 PM
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Originally Posted by Wildwood
A futurist - exercise in a pill - how wonderfully American.
Let's have a suntan pill too, so we can look outdoorsy year-round. Just not too Orangey.
"and the one's that Mother gives you don't do anything at all."
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Old 09-07-23, 07:20 PM
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Originally Posted by MoAlpha
A quick search says MYC protein plays a role in the control of cell growth. Pretty sure this project is aimed at laying out some of the critical steps between the mechanical effect of exercise and muscle cell growth or preservation, and to find out how aging affects them. One possible outcome from this type of work could be "exercise in a pill" for, say, people on prolonged bedrest.
While posting on another thread, I saw a study where they gave whey protein to patients on chemo and found a major jump in muscle response at 40g/day. I was surprised at that quantity. IIRC, the study didn't have much information on the activity level of the patients. Hmmm. Maybe so. It didn't seem to me that MYC supplementation was in the offing, just trying to figure out how all that works.

We already have some of that in HMB. An older female friend who rides and hikes was like OMG that works! But only on that level for geezers, though I do wonder if young athletes are using it. I also wonder if exogenous is detectable.
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Old 09-07-23, 10:14 PM
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Moderation Note. Sorry guys, we had to delete the copyrighted material. Good topic. We suggest OP paraphrase the article and reference a link. We understand the article may be behind a paywall, however, that does not change the rules.
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Old 09-08-23, 06:59 AM
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Originally Posted by Carbonfiberboy
While posting on another thread, I saw a study where they gave whey protein to patients on chemo and found a major jump in muscle response at 40g/day. I was surprised at that quantity. IIRC, the study didn't have much information on the activity level of the patients. Hmmm. Maybe so. It didn't seem to me that MYC supplementation was in the offing, just trying to figure out how all that works.

We already have some of that in HMB. An older female friend who rides and hikes was like OMG that works! But only on that level for geezers, though I do wonder if young athletes are using it. I also wonder if exogenous is detectable.
I haven't heard of any younger athletes using HMB and my question is whether it works when you're getting enough leucine in the diet. Seems to me a slug or two of whey protein a day would take care of that. Who knows what them old folks is eating.
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Old 09-08-23, 11:34 AM
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Originally Posted by MoAlpha
I haven't heard of any younger athletes using HMB and my question is whether it works when you're getting enough leucine in the diet. Seems to me a slug or two of whey protein a day would take care of that. Who knows what them old folks is eating.
I do know that another BF member and I started using HMB, but never heard if he realized any benefits. I canít say it increased performance or reduced muscle soreness but we both experienced a decided slowing of our urine streams. Evidently with some ingesters, it affects the prostate. After discontinuing, I did not notice any decrease in performance or additional muscle soreness but urination output was restored to previous levels. For some HMB works without side effects, but am happy to be saving the money (and after-taste). Carbonfiberboy is enjoying the benefit and hope it continues.

I also stopped using concentrated beet powder after developing kidney stones (2 episodes) for the first time. After discontinuing, no recurrence. Just depends on each individualís ability to metabolize.
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Old 09-08-23, 01:05 PM
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Originally Posted by MoAlpha
I haven't heard of any younger athletes using HMB and my question is whether it works when you're getting enough leucine in the diet. Seems to me a slug or two of whey protein a day would take care of that. Who knows what them old folks is eating.
Leucine is about 10% of whey protein isolate, so 30g isolate = 3g leucine. About 5% of leucine is converted to HMB = .15g from the 30g of isolate. OTOH the recommended dose of HMB is 3g/day, 20 times as much or ~7 times as much as from 3-30g doses of isolate. HMB will even protect bed-ridden patients from muscle loss. My understanding is that HMB works better when combined with whey protein. The effect is quite noticeable.
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Old 09-08-23, 01:12 PM
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Originally Posted by rsbob
I do know that another BF member and I started using HMB, but never heard if he realized any benefits. I can’t say it increased performance or reduced muscle soreness but we both experienced a decided slowing of our urine streams. Evidently with some ingesters, it affects the prostate. After discontinuing, I did not notice any decrease in performance or additional muscle soreness but urination output was restored to previous levels. For some HMB works without side effects, but am happy to be saving the money (and after-taste). Carbonfiberboy is enjoying the benefit and hope it continues.

I also stopped using concentrated beet powder after developing kidney stones (2 episodes) for the first time. After discontinuing, no recurrence. Just depends on each individual’s ability to metabolize.
I didn't notice a diminished stream, but I do have to pee more frequently. I'm willing to put up with that in return for having my youthful strength back. Beet powder is problematic. 1g/day of the active ingredient, sodium nitrate, does the same thing, no side effects noted in the past 20 years. The HMB dose needs to be timed, 1g before, 1g after, 1g 3 hours or so after.
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Old 09-09-23, 08:47 AM
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Originally Posted by Hermes
Moderation Note. Sorry guys, we had to delete the copyrighted material. Good topic. We suggest OP paraphrase the article and reference a link. We understand the article may be behind a paywall, however, that does not change the rules.
Originally Posted by AP article
FAYETTEVILLE, Ark. (AP) ó The effect of exercise on aging will be studied at the University of Arkansas at Fayetteville, thanks to a $2.5 million grant from the National Institutes of Health.
https://apnews.com/article/universit...21182ef5bcbe0#

Dan

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Old 09-09-23, 10:19 AM
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Originally Posted by Carbonfiberboy
I didn't notice a diminished stream, but I do have to pee more frequently. I'm willing to put up with that in return for having my youthful strength back. Beet powder is problematic. 1g/day of the active ingredient, sodium nitrate, does the same thing, no side effects noted in the past 20 years. The HMB dose needs to be timed, 1g before, 1g after, 1g 3 hours or so after.
I used HMB for a while. Found some literature about interaction between the prostate and hmb and saw no improvement, and felt the risk is not worth the possible benefit and stopped.
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