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BF docs: How do blood types work?

Old 02-10-17, 12:52 PM
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banerjek
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BF docs: How do blood types work?

We all get taught that people have different blood types, O negative can donate to anyone, AB positive can receive from everyone, etc.

But if adding my AB+ to someone's O- blood causes a reaction, why does adding their O- to my AB+ not cause the same reaction since the blood gets mixed together either way?

Or is what's really going is that the body reacts to the blood and mixing blood doesn't cause problems in and of itself until you put it in someone's body?
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Old 02-10-17, 01:19 PM
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Originally Posted by banerjek View Post
Or is what's really going is that the body reacts to the blood and mixing blood doesn't cause problems in and of itself until you put it in someone's body?
Yes, it's what types of protein on the red blood cells your body will react to and treat as a foreign substance. If you have AB+ blood (i.e. with both A and B type proteins on your red blood cells) then your body accepts all the proteins as normal and won't react to them whereas someone with O- would have a reaction to any other type of blood since their own blood doesn't have those proteins.
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Old 02-10-17, 01:30 PM
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Originally Posted by prathmann View Post
Yes, it's what types of protein on the red blood cells your body will react to and treat as a foreign substance. If you have AB+ blood (i.e. with both A and B type proteins on your red blood cells) then your body accepts all the proteins as normal and won't react to them whereas someone with O- would have a reaction to any other type of blood since their own blood doesn't have those proteins.
That's what I get for getting ideas from TV shows.

What prompted the question was I was watching a historical drama set around the turn of the century where a doctor understood that certain blood combinations were OK and some were not. But when I saw the mechanism he used to figure out what combinations were OK -- putting a drop of each combination on a slide to see what coagulated and what didn't -- it made no sense.
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Old 02-10-17, 01:34 PM
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ABO blood types are characterized by specific proteins on the red cell surfaces.

A and B have antigens on the cells that will cause an immune response in people who haven't grown up with them. O doesn't have those antigens so doesn't cause a problem for people who get that blood type whether or not it matches what they grew up as.

+ is separate antigen that doesn't do anything to/for people who have it, but is bad for people who don't have it. -, absence of that protein, doesn't do anything bad to people who do have it.
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Old 02-10-17, 02:33 PM
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There are too many factual answers here for foo.
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Old 02-10-17, 02:59 PM
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Originally Posted by banerjek View Post
That's what I get for getting ideas from TV shows.

What prompted the question was I was watching a historical drama set around the turn of the century where a doctor understood that certain blood combinations were OK and some were not. But when I saw the mechanism he used to figure out what combinations were OK -- putting a drop of each combination on a slide to see what coagulated and what didn't -- it made no sense.
I'm not quite sure how they do (or historically did) the blood tests. I'm surprised that it would effect coagulation. But, perhaps it would affect the prothrombin time somewhat.

The Coombs test was apparently developed in the 1940's, but there was research into blood groups as early as the turn of the century.
https://en.wikipedia.org/wiki/Coombs_test#History
https://en.wikipedia.org/wiki/Blood_type#History

Anyway, an astute physician from the early 1900's should be able to separate blood cells from plasma (centrifuge). Most of the IgG Immunoglobulin will come out in the plasma. And the ABO+ antibodies would remain with the cells.

So, one could design an asymmetrical test by centrifuging the blood from the two patients. Then mixing cells from patient A and plasma from patient B (or visa-versa).
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Old 02-10-17, 06:10 PM
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I recently had to take a blood test, so I studied all night and got an A+ (blood type)
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Old 02-10-17, 06:26 PM
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In Japan and Korea, your blood type is kind of like your horoscope.

Blood type personality theory


Type AB:

Best traits:
Cool, controlled, rational, sociable, adaptable and intelligent

Worst traits:
Critical, indecisive, unforgiving, two-faced, aloof and "split personality"

Heh.
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Old 02-10-17, 06:34 PM
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Originally Posted by up on two View Post
I recently had to take a blood test, so I studied all night and got an A+ (blood type)
Lucky dog. I studied all night for a urine test and failed
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Old 02-10-17, 10:15 PM
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Originally Posted by banerjek View Post
Lucky dog. I studied all night for a urine test and failed
Had that happen once, realized I had been studying the wrong material.
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Old 02-11-17, 08:29 AM
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Originally Posted by banerjek View Post
Lucky dog. I studied all night for a urine test and failed
I won my last pissing contest
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Old 02-11-17, 03:29 PM
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Originally Posted by no motor? View Post
There are too many factual answers here for foo.
People with type A make vitamin D from UV-A rays, and those with type B use UV-B rays. Type O can not make their own vitamin D, must never go out in the sun, and can only get vitamin D from stealing blood from others in the night.

Positive blood means you have antibodies to protect against freckles. Negative blood type means you don't, and you can catch freckles from a ginger and become a ginger.

If you donate blood, you lose a bit of your soul each time. If you give more than 3 quarts in your lifetime, you could lose your soul completely and become a mid-level manager.

The exception is type O-negative, as gingers have no soul to lose, hence these are considered universal donors.

No, you can't catch ginger from ginger blood. It is only transmitted by thumb wrestling, fraternity or gang style handshakes, high fives and exploding fist bumps.
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Old 02-13-17, 05:13 PM
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Originally Posted by banerjek View Post
We all get taught that people have different blood types, O negative can donate to anyone, AB positive can receive from everyone, etc.
I've never been taught about blood types. I am aware there are types of blood, there are As and Bs involved, and some types don't mix well with other types. And I've donated blood a bunch of times. And I have a PhD and I wrote my dissertation on a topic of bioinformatics/genomics.

But I don't know my own type or anybody else's.

Hm, just checked, my driver's license says I am a donor, but doesn't say my blood type. Don't you think that would be useful information?
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Old 02-13-17, 06:22 PM
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Originally Posted by RubeRad View Post
Hm, just checked, my driver's license says I am a donor, but doesn't say my blood type. Don't you think that would be useful information?
Tissue typing is much more complex than blood typing, so blood type isn'the important for that.

It might be important for emergency first aid, but I think ambulances typically just administer IV fluids, not whole blood.
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Old 02-15-17, 08:44 AM
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Originally Posted by banerjek View Post
What prompted the question was I was watching a historical drama set around the turn of the century where a doctor understood that certain blood combinations were OK and some were not. But when I saw the mechanism he used to figure out what combinations were OK -- putting a drop of each combination on a slide to see what coagulated and what didn't -- it made no sense.

Was it "The Knick"? Loved that show. Shame it didn't keep going.
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Old 02-15-17, 09:19 AM
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The RH factor part is a little tricky compared to the ABO blood groupings. Even though we say rh-positive and rh-negative based on whether it's present or not, similar to the ABO concept, there are a whole slew of Rh antigens with four or five of them being important if I recall correctly. Which means that it's not really binary with respect to donor/accepting Rh-positive blood. Some types of Rh-negative can accept some types of Rh-positive and so on.
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Old 02-15-17, 09:43 AM
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TIL: Type O Negative can give to anyone, and AB Positive can get from anyone.

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Old 02-16-17, 05:32 PM
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Originally Posted by indyfabz View Post
Was it "The Knick"? Loved that show. Shame it didn't keep going.
It was "Ripper Street." The show is set around the turn of the century and the main character is a sort of medical Macgyver who solves murders using inventive methods.
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Old 02-16-17, 06:19 PM
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Blood banker here.
A and B antigens are on red cells. Everyone makes antibodies to the A or B antigens they lack(the antigens are similar to environmental antigens we are all exposed to, so we create antibodies to those antigens deemed not self). Blood containing anti-A (type B) will coagulate with type A or AB red cells(which can kill you). Rh pos or neg is a bit different in that we usually only make anti-D(Rh) upon exposure to Rh positive blood. Cool stuff!
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Old 02-17-17, 12:06 AM
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whenever I think about this subject, I suspect that, historically, some really hard lessons were learned by people who needed blood.

I'm O-, so I give whenever I can because the rest of you vampires are very needy. And I feel compelled to help out all the other people with O-neg blood because we have to look after each other -- nobody else is.
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