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Exercise Pill: Burns fat w/o moving a muscle

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Exercise Pill: Burns fat w/o moving a muscle

Old 07-31-08, 04:19 PM
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Exercise Pill: Burns fat w/o moving a muscle

With this pill , would you give up cycling and exercise. Second question, how does one get a mouse to become an exercise addict.
????


NEW YORK — Here's a couch potato's dream: What if a drug could help you gain some of the benefits of exercise without working up a sweat? Scientists reported Thursday that there is such a drug _ if you happen to be a mouse.

Sedentary mice that took the drug for four weeks burned more calories and had less fat than untreated mice. And when tested on a treadmill, they could run about 44 percent farther and 23 percent longer than untreated mice.

Just how well those results might translate to people is an open question. But someday, researchers say, such a drug might help treat obesity, diabetes and people with medical conditions that keep them from exercising.

"We have exercise in a pill," said Ron Evans, an author of the study. "With no exercise, you can take a drug and chemically mimic it."

Evans, of the Salk Institute for Biological Studies in La Jolla, Calif., and the Howard Hughes Medical Institute reports the work with colleagues in a paper published online Thursday by the journal Cell.

They also report that in mice that did exercise training, a second drug made their workout much more effective at boosting endurance. After a month of taking that drug and exercising, mice could run 68 percent longer and 70 percent farther than other mice that exercised but didn't get the drug.

In fact, Evans said that when the experiment with sedentary mice was suggested by an outside scientist who was reviewing the lab's research, "I didn't think it was going to work."

The no-exercise drug is called AICAR. Previous experiments suggest that it might protect against gaining weight on a high-fat diet, which might make it useful for treating obesity, Evans said. But it would have to be taken for a long time, he said, so its safety in people would have to be assured.

https://www.huffingtonpost.com/2008/0..._n_116170.html
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Old 07-31-08, 06:28 PM
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The fat just walks away! (Okay, who had the Adipose icon?)
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Old 07-31-08, 07:16 PM
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Great, let's make sedentary people have a reason to be even more sedentary! Perhaps for those people who cannot physically exercise but for those lazy asses who won't, I say no way. I really really wish more money was spent teaching proper diet, nutrition & exercise. I hate magic pills.

To answer the question though, no way in a million years. I love to suffer on my bikes, it's better than sex to me!
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Old 07-31-08, 08:23 PM
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something for nothing...Imagine that claim.
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Old 07-31-08, 08:57 PM
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Originally Posted by cyclezealot View Post
What if a drug could help you gain some of the benefits of exercise without working up a sweat?
It would be quite some drug that would give me the benefits of exercise ... benefits like ...

-- time alone on my bicycle to think through and resolve problems

-- breathing fresh air and feeling the warmth of the sun

-- being able to see and experience scenery, like in this photo set, for example:
https://www.flickr.com/photos/1430288...7605871338498/

-- spending time with other cyclists who also enjoy being out in nature

-- experiencing the satisfaction of knowing I've gone somewhere and done something

-- meeting challenges

-- having adventures

Last edited by Machka; 07-31-08 at 09:29 PM.
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Old 07-31-08, 09:01 PM
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So Machka- you get the pills, a fan, a heat lamp, and a Viewmaster, and there you go!

Serously, I agree. The challenge with exercise is not just doing it, but finding something that you like doing, and that's why I've been riding a bike. If it was jog on a treadmill or take a pill, the pill would sound a lot better.
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Old 07-31-08, 09:27 PM
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>>>To answer the question though, no way in a million years. I love to suffer on my bikes, it's better than sex to me! <<<

You obviously haven't been with the right woman. :-)
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Old 07-31-08, 09:55 PM
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Originally Posted by DavidLee View Post
Perhaps for those people who cannot physically exercise but for those lazy asses who won't, I say no way. I really really wish more money was spent teaching proper diet, nutrition & exercise. I hate magic pills.
And therein lies the problem. My friend and I were discussing this today. Assuming this actually works in humans (I'm still waiting for mice to take over the world since EVERYTHING works in mice) it will end up being a resticted substance that is only prescribed for people with medical conditions that prevent them from exercising and a felony for doctors to prescribe or anyone to obtain otherwise. Would I stop riding my bike if I could get this drug? HELL NO! For all the reasons already mentioned. I LIKE riding my bike! But would I want to take it? Oh hell yeah. And why not? Assuming it had no terrible side affects (sudden death, possesion by the prince of darkness, your children born with the head of a golden retriever, erections lasting longer than four hours, etc...). Where can I get some?
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Old 07-31-08, 10:14 PM
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The real fun begins when you have ultra fit people taking this stuff.

You'll be looking at 600 mile 20 hour stages in the TDF.
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Old 07-31-08, 10:36 PM
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The second pill, the one that increases endurance, could be scary...

I have the genetic version of the first drug. My metabolism is stuck somewhere between "hummingbird" and "shrew." Unfortunately, those also describe my attention span and my interpersonal skills, some days... thin's not all it's cracked up to be.
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Old 07-31-08, 10:39 PM
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I'd welcome a pill that boosted my endurance and nudged my muscles into burning fat more readily. Would be a boon to those of us whose metabolisms force us to vigilantly watch our diet and exercise regularly to avoid plumping.

But it wouldn't replace exercise. Besides the numerous benefits Machka mentions, it also wouldn't do a thing for cardiovascular condition. Those of the fast-food munching, TV-vegging couch potato lifestyle may still drop from a heart attack by their 40s. But their remains will be less corpulent.
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Old 07-31-08, 11:08 PM
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Originally Posted by saxonrider View Post
>>>To answer the question though, no way in a million years. I love to suffer on my bikes, it's better than sex to me! <<<

You obviously haven't been with the right woman. :-)
Or man.
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Old 08-01-08, 01:26 AM
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Originally Posted by annc View Post
Or man.
I prefer people, because it can mean either/or more than one...
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Old 08-01-08, 06:50 PM
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Originally Posted by annc View Post
Or man.
Easy there now, let's play nice.
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Old 08-02-08, 10:05 AM
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The world has more than enough "muscle" heads to go around!!
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Old 08-02-08, 10:25 AM
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To answer the question though, no way in a million years. I love to suffer on my bikes, it's better than sex to me!
I hear they are coming up with a pill for sex too!
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Old 08-02-08, 11:16 AM
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Reminds me of a chapter in a little children's book. Chapter 23, for anyone interested:

https://wikilivres.info/wiki/index.php/The_Little_Prince
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Old 08-02-08, 11:53 AM
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Nope. I ride for fun, not for exercise.
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Old 08-02-08, 02:51 PM
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Originally Posted by cyclezealot View Post
They also report that in mice that did exercise training, a second drug made their workout much more effective at boosting endurance. After a month of taking that drug and exercising, mice could run 68 percent longer and 70 percent farther than other mice that exercised but didn't get the drug.
Assuming the effectiveness of this drug in humans, why is it an either/or question. I'd love to be able to ride 68% longer and 70% farther than those guys who are saying they wouldn't take it. What's the downside? What, it's not fair? So what? It's not fair that some people are born to be 150-lbs with 6% body fat and 7-ltr lung capacity or somebody else has a job and family schedule that lets them ride/train twice as much either but them's the breaks. Where do I sign up for the trial?
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Old 08-02-08, 06:27 PM
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I listen to NPR's Science Friday religiously, and this week they interviewed the scientist engaged in the research. You can listen to the segment in streaming audio here:

https://www.sciencefriday.com/program/archives/200808014

Note that the drug has ONLY been tested in mice; no human trials whatever have been performed. The intent of the drug is theraputic, allowing severely debilitated people the benefits of exercise. Note also that realizing the potential for abuse, the researchers have already prepared a testing protocol and submitted it to the international doping commission.
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Old 08-02-08, 06:48 PM
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Well, I'm with a lot of others -- I wouldn't stop riding for ANYTHING! Threaten my children with immediate and painful death unless I stop, and I'll stop. But nothing else -- not even my own death! If I couldn't ride, why live?

If available, I'd take the pill, though -- for those hours when I can't ride, and for the wintertime when all I can do is short rides to/from work.

International doping commission? I'm not a racer, so I'll whiz on your pant leg -- test THAT!
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Old 08-02-08, 07:15 PM
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Originally Posted by ATAC49er View Post
International doping commission? I'm not a racer, so I'll whiz on your pant leg -- test THAT!
Exactly!
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Old 08-02-08, 07:28 PM
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Originally Posted by Bikewer View Post
The intent of the drug is theraputic, allowing severely debilitated people the benefits of exercise.
You realize that if they discovered something that would cause you to stop aging immediately and revert to your physical condition and appearance at say age 25 and be able to run marathons 6 days a week it would still be a theraputic drug only for people with health issues. The FDA doesn't consider either aging or lack of native athletic potential to be diseases and as such would not approve any drug to "treat" those conditions. And without the possibility of approval drug companies are not going to invest in the research and trials required to insure that the drug is safe and effective. Our loss. I suspect even the existing performance enhancing drugs (synthetic testoterone, steroids, HGH, EPO, you name it) could be used safely and effectively if the studies were done to determine appropriate dosing and you were monitored by a medical professional while using them.
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Old 08-02-08, 08:22 PM
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Better living through pharmaceuticals! I'm sure this one won't have any horrific side effects that don't show up for months or even years! I'm sure it'll be a magic bullet, and cheap to boot!

Drogen über alles!

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Old 08-02-08, 11:07 PM
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Originally Posted by x136 View Post
Better living through pharmaceuticals! I'm sure this one won't have any horrific side effects that don't show up for months or even years! I'm sure it'll be a magic bullet, and cheap to boot!

Drogen über alles!

IF it were appropriately tested in well designed drug studies, approved by the FDA, produced by the major drug companies, and its use monitored by medical professionals and with a bit of luck, I suspect it could be quite safe, cheap, and effective. On the other hand I doubt those things will happen. What will actually happen is small studies will be conducted only on people with serious medical conditions rendering the results useless for performance enhancement purposes, availability of the drug will be limited and expensive, the government will get involved and make it a controlled substance and then the only way to get or use the drug will be through illegal back channels so you'd end up getting fake drugs or something with rat poison in it, its use will not be monitored, athletes looking for a perfomance edge will experiment and sometimes overdose on it, it'll get bad press and when we check back here on the forum in a few years the naysayers will be saying, "I told you so" and the DEA will be annoucing a big sting operation to bust the heinous criminals who were on some other forum somewhere trying to discuss how to use it. Damn, do I sound cycnical? Just reality.
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