does it really make a difference what side your quick release faces?
 

driver's side, drive side? is it like putting my cranks on the left side and waiting for the pedals to come off?

Do you run disc brakes?

I don't think there is a reason for one side or the other except for disc brakes and getting them caught in rotors.

No. On a geared bike, it's easier to put the lever on the non drive side because the derailleur gets in the way of the handle.

Other than that, it's just visual symmetry. I guess.

quick releases go on the non-drive side. tires face drive side and their labels should be paired up with or opposite of the valve.

this is simply how things are done. it's a detail thing.

quick release levers on the drive side is like wearing polo shirts tucked into khakis.
you won't end up in the emergency room, but that's not the point...

it's funny because some people talk ish if you put it on the drive side. one of my front wheels is q/r and it points whichever way it lands in the fork.

lols fred.

fred? at least i'm not looking for a discount tandem.

pwn3d.

i feel like extending this metaphor.

quick release levers on the drive side is like:

1. wearing your belt buckle on the right side
2. wearing your watch on your dominant wrist
3. wearing a brown belt with black shoes
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*more to come. maybe.

ask the freds in road & see wha'happens.