I had a colonoscoy done in December and had moderate to severe abdominal cramps for five days after plus some bleeding the day after because of polyp removal. My MD said I had a prticularly "tortuous" colon. lots of twists and turn, so he really had to work hard to get the apparatus through. My wife had a colonoscopy two years ago and we were hiking into the Grand Canyon two days later with no difficulty. There is no way to tell what the aftereffects might be till the doc gets in there.