i'm running 44x16, no problems! as Judah mentioned, there's always a way around the hills. plus, you get to put in more miles this way.
on an aside, i'm very proud of myself for getting to the top of twin peaks on 44x16. really hard work, but damn rewarding. we should do a twin peaks ride some time! from up there, it takes approximately 40 seconds to make it to the Zeitgeist and get a Stella in hand