Originally Posted by
Nate552
150 micrograms per milliliter in your urine. You would need to know how much you are taking, it's half life, and it's excretion levels. (from my wife who is in the Texas Tech Masters Program for NP)
8.4 EXCRETION
8.4.1 KIDNEY
A) 55% to 75% is excreted unchanged in the urine (USPDI, 1999). Up to 88% of a dose is excreted unchanged in the urine after 36 hours (Bye et al, 1974).
B) Renal excretion is accelerated with acidic urine (USPDI, 1999).
8.5 ELIMINATION HALF-LIFE
8.5.1 PARENT COMPOUND
A) GENERAL
1) 1.9 to 21 hours (urine pH dependent). The half-life was 50 hours in a patient with renal tubular acidosis and persistent alkaline urine (Brater et al, 1980).
1974, 1980, 1999... WADA is slightly more up to date as found in the link Ex provided.
Given the wide availability of PSE-containing medicines, WADA recommends that the
reintroduction of PSE be supported by an active information/education campaign by all
stakeholders.
In this regard, WADA recommends that the following information be communicated, as soon
as possible, to Athletes and their support personnel:
-The established threshold levels may be reached (rarely, but possibly) by some
individuals within 6-20 hours of intake of some long-lasting therapeutic formulations.
-Advise athletes to stop taking PSE pills at least 24 hours before competition.
For therapeutic applications during the In-Competition period, consider the use of
alternative permitted medications upon previous consultation with a physician, or
apply for a Therapeutic Use Exemption (TUE) for the use of PSE for therapeutic
purpose(s).
- The threshold level has been established based on the intake of therapeutic doses of
PSE, defined as a maximum daily dose of 240mg PSE taken either as:
i) four (4) daily administrations (one every 4-6 hours) of a 60mg pill
(or 2 x 30mg pills), or
ii) two (2) daily administrations (one every 12 hours) of a 120mg pill
(extended release), or
iii) one (1) daily administration of a 240mg pill (extended release).
-In line with this dosing regimen, the intake, for example, of a single daily dose of 3 x
60mg pills constitutes a supratherapeutic administration that may lead to an Adverse
Analytical Finding.
References
1- Gill N.D. et al (1999). Br J Clin Pharmacol 50, 205-213.
2- Chester N. et al. (2003). Br J Clin Pharmacol 57 :1, 62-67
3- Hodges K. et al. (2006). Med & Science Sports & Exercise, 329-333
4- Strano-Rossi S et al. (2209). Ther Drug Monit 31: 520-526.
5- Deventer K. Et al. (2009). Drug Test Analysis 1, 209-213.