Originally Posted by
Enthalpic
1974, 1980, 1999... WADA is slightly more up to date as found in the link Ex provided.
Given the wide availability of PSE-containing medicines, WADA recommends that the
reintroduction of PSE be supported by an active information/education campaign by all
stakeholders.
In this regard, WADA recommends that the following information be communicated, as soon
as possible, to Athletes and their support personnel:
-The established threshold levels may be reached (rarely, but possibly) by some
individuals within 6-20 hours of intake of some long-lasting therapeutic formulations.
-Advise athletes to stop taking PSE pills at least 24 hours before competition.
For therapeutic applications during the In-Competition period, consider the use of
alternative permitted medications upon previous consultation with a physician, or
apply for a Therapeutic Use Exemption (TUE) for the use of PSE for therapeutic
purpose(s).
- The threshold level has been established based on the intake of therapeutic doses of
PSE, defined as a maximum daily dose of 240mg PSE taken either as:
i) four (4) daily administrations (one every 4-6 hours) of a 60mg pill
(or 2 x 30mg pills), or
ii) two (2) daily administrations (one every 12 hours) of a 120mg pill
(extended release), or
iii) one (1) daily administration of a 240mg pill (extended release).
-In line with this dosing regimen, the intake, for example, of a single daily dose of 3 x
60mg pills constitutes a supratherapeutic administration that may lead to an Adverse
Analytical Finding.
References
1- Gill N.D. et al (1999). Br J Clin Pharmacol 50, 205-213.
2- Chester N. et al. (2003). Br J Clin Pharmacol 57 :1, 62-67
3- Hodges K. et al. (2006). Med & Science Sports & Exercise, 329-333
4- Strano-Rossi S et al. (2209). Ther Drug Monit 31: 520-526.
5- Deventer K. Et al. (2009). Drug Test Analysis 1, 209-213.