My last two rides has been a sorta revelation to me. I am 215Ibs, ride a carbon Lemond, 23mm tires that are always inflated to 120psi front and back. My typical ride is about 60miles. I am currently "experimenting" with tire pressures. My last two rides had my front tire at 100psi and my rear at 110psi, and I could not believe how much better I felt after the rides.
I am sorta worried about pinch-flatting(especially at my weight), but the lower pressure and resulting comfort is making a believer out of me.