I totally agree that the Supreme is an awesome tire. The 37-622 rides very smoothly and it really gives confidence on wet pavement. It's my choice for the front tire when touring on asphalt. When touring off-road I'd rather have a little tread on the tire edges as in the Dureme (which I've not yet used). Unfortunately, the Extreme is not available in 622 in wider widths.
But I have already worn out 3 Supreme tires - used in combinations of front and rear - in half the mileage (3500 miles) compared to same-sized XR's in similar conditions. I also got many more flats (1/500 miles versus 1/7000 miles). Tire failure on the Supremes is at the tread, while failure in the XR is in the sidewall. The softer rubber is the reason for its relative advantages and disadvantages versus the XR, since the protection layer is apparently the same in both tires.
Schwalbe EVO series tires are indeed expensive, but not if your alternative is a cheaper tire with a Kevlar liner (SpinSkins, Flataway).
Supremes are available from Wallbike.